Univ.-Prof. Dr. Christian Singer

Univ.-Prof. Dr. Christian Singer

Fachgebiete: 
Frauen­heil­kunde und Geburts­hilfe
Spezialisierung
  1. Brustkrebs, Brustgesundheit
  2. Wechselbeschwerden, Gynäkologische Endokrinologie
Sonstiges

BREAST & HEALTH Zentrum für Brustgesundheit

Ordination
Ordinationszentrum Döbling – Ebene 1
Heiligenstädter Straße 46-48
(gegenüber dem Haupteingang der Privatklinik Döbling)
1190 Wien

Ordinationszeiten:
Dienstag: 16:30 - 19:00
Donnerstag: 16:30 - 18:30
Lebenslauf

Education

 

 

2003 - 2005     Master of Public Health Graduate Program, Harvard University School of Public Health, Harvard University, Boston, MA, USA

 

1984 – 1990   Medical School, University of Innsbruck, Innsbruck, Austria

 

1976 – 1984   High School, Bundesrealgymnasium Reutte, Austria. Degree awarded with honors

 

 

Professional Experience

 

 

2011 -                         Full Professor of Clinical-Translational Gynecological Oncology, Vienna University Medical School, Vienna, Austria

 

2009 -                         Head of Senology, Department of OB/GYN, Vienna University Medical School, Vienna, Austria

 

2007 –2009     Deputy Head, Division of Special Gynecology, Department of OB/GYN, Vienna University Medical School, Vienna, Austria

 

2006 - 2007    Senior Clinical Specialist and Deputy Medical Director, Prince Court Medical Centre, Kuala                              Lumpur, Malaysia

 

2002 -             Founder and CEO, Hellmann & Moedlinger Ltd, Public Health Consulting

 

2000 -             Expert Evaluator, European Commission, Brussels, Belgium

 

2003 - 2011    Associate Professor of Obstetrics and Medical Gynecology, Division of Special Gynecology,                               Medical University of Vienna, Austria

 

1997 - 2003     Assistant, Department of Special Gynaecology, Vienna University Medical School, Vienna, Austria

 

1995 – 1997    Postdoctoral Fellow, DeDuve International Institute for Cellular Pathology (ICP), Université Catholique de Louvain, Brussels, Belgium

 

1994 – 1995    Residency, Department of OB/GYN, Klinikum rechts der Isar - Technical University Hospital, Munich, Germany

 

1991 – 1993    Postdoctoral Fellow, Lombardi Cancer Research Center, Georgetown University, Washington, DC, USA

 

 

Additional training

 

 

2001                           Johnson & Johnson European Healthcare Leadership Programme, INSEAD, Fontainebleau, France

 

1998 -                                     Graduate courses in Law, Vienna University, Faculty of Law, Vienna, Austria

 

1992               Graduate courses in Molecular Biology, Georgetown University, Washington, DC, USA

 

1988                           Advanced Studies Program in Clinical Pharmacology, Department of Medical Pharmacology, Innsbruck University Medical School, Innsbruck, Austria

 

 

Licenses and certifications

 

2006               Clinical Trial Investigator Certificate, Austrian Medical Association, Vienna, Austria

 

2004               OB/GYN License, Austrian Medical Association, Vienna, Austria

 

1996                           USMLE Certificate, Educational Commission for Foreign Medical Graduates (ECFMG), USA

 

1995               Medical License, German Medical Association, Munich, Germany

 

 

Fellowships and awards

 

2007                           Researcher of the Month, Medical University of Vienna, Vienna, Austria

 

2004                           Award of the Austrian Society for Senology´, Austrian Society for Senology, Vienna, Austria

 

2003                           Forschungspreis des Fonds der Stadt Wien für innovative interdisziplinäre Krebsforschung, Viennna, Austria

 

2003                                       Research Fellowship, Menachem-Elias Foundation, Vienna Austria

 

1999                           Research Award of the `Erste Bank der österreichischen Sparkassen AG´, Erste Bank, Vienna, Austria

 

1999                        `Hugo Husslein  Award´, Austrian Society for Obstetrics and Gynecology, Vienna, Austria

 

1999                        `Hans und Blanka Moser-Award´, Hans und Blanka Moser-Foundation, Vienna, Austria

 

1999                        `Schönmann-Cancer Research Award´, Schönmann Foundation, Vienna, Austria

 

1998                        `Theodor-Körner-Award`, Theodor-Körner Foundation, Vienna, Austria

 

1998                           Award of the Austrian Society for Senology´, Austrian Society for Senology, Vienna, Austria

 

1998               `HOECHST-Award´, Hoechst Austria AG, Vienna, Austria

 

1996                           `Haas-Teichen Fellowship`, DeDuve International Institute for Cellular Pathology, Brussels, Belgium

 

1995                           `ICP Fellowship´ - International Institute for Cellular and Molecular Pathology, Brussels, Belgium

 

1993               `Eduard Wallnöfer Award´ - State Council of the Tyrol, Innsbruck, Austria

 

1991                           `Auslandsstipendium zur Förderung wissenschaftlicher Arbeiten´ Scholarship - Austrian Federal Department of Science and Research, Vienna, Austria

 

1986                           `Young Researcher Award´ - Philips Industries and Austrian Federal Department of Schience and Research, Vienna, Austria

 

 

Professional memberships

 

 

 

Member of the Board, Austrian Society of Obstetrics and Gynecology (OEGGG)

 

Member of the Board, Austrian Society of Senology (OGS)

 

Member of the Board, Austrian Society for Gynecological Oncology (AGO)

 

Member, American Society of Clinical Oncology (ASCO)

 

Member, American Association for Cancer Research (AACR)

 

Member, Austrian Society for Public Health (APH)

 

Member, Harvard University Alumni Association

Publikationen

Books and Bookchapters

 

 

Singer CF (2009) Ethik und medizinisches Screening (Fischer M and Hengstschläger M ed), Peter Lang, Internationaler Verlag der Wissenschaften, in preparation

 

Singer CF (2009) Prognosefaktoren und prädiktive Faktoren beim Mammakarzinom: vom Hormonrezeptor zum Gen Chip, in Strahlentherapie und Onkologie 2009/2010. ISBN 978-3-940671-16-5 Düsseldorf University Press

 

Kubista E, Singer CF (2009) Zielgerichtete Therapien zur Therapie des Mammakarzinoms. Uni-Med Verlag Publishers, Bremen, in preparation

 

Singer CF (2009) Epidemiologie des Mammakarzinoms. Manual der Gynäkologischen Onkologie (A Reinthaller, L Hefler, ed.) ISBN 978-3-9501446-1-1, MedMedia Verlag, Vienna

 

Menzel CR, Singer CF, (2009) Brustaufbau. Manual der Gynäkologischen Onkologie (A Reinthaller, L Hefler, ed.) ISBN 978-3-9501446-1-1, MedMedia Verlag, Vienna

 

Kubista E, Singer CF, Seifert M (2008) Aromatasehemmer in der endokrinen Therapie des Mammakarzinoms ISBN 978—89599-280-3, Uni-Med Verlag Publishers, Bremen

 

Singer CF, Gschwantler-Kaulich D, Fink-Retter A, Kubista E, Czerwenka K and Hudelist G (2006) Significance and Prognostic Value of Estradiol Modulating Enzymes in Breast Cancer. New Research Communications of Tumor Markers (F. Columbus, ed.) Nova Science Publishers, in press

 

Hudelist G, Czerwenka K, Kubista E, Wieser F, Tschugguel W, and Singer CF (2005) Interleukin-1 System and Sex Steroid Receptor Gene Expression In Human Endometrial Cancer. Ovarian Cancer, New Research (A.P. Bardos, ed.) ISBN 1594542414, Nova Science Publishers

 

Singer CF, Rasmussen A, Lippman ME, and Cullen KJ (1999) Breast cancer cells influence the pattern of cytokine expression in neighbouring breast fibroblasts via paracrine interactions. Proc. 11th Int. Meeting of the Eur. Soc. Of Gyn. Onc. (Bosze, Maggino, De Oliveira et Onnis, ed.) Monduzzi Editore, 3-7

 

Kokorine I, Nisolle M, Donnez J, Singer CF, Galant C, Eeckhout Y, Courtoy PJ, and Marbaix E (1999) Matrix Metalloproteinases and endometriosis. Understanding Endometriosis: Proc. VIth Int. World Congr. on Endometriosis, (A. Lemay, ed.) Parthenon Publ. Press, 239-250

 

Singer C (1987) `Der Plansee - History and Scenary of an Austrian Lake`, ISBN 3-85423-074-5, Steiger Publishing Company, Innsbruck, Austria

 

 

 

Scientific Papers

 

 

Antoniou AC, Sinilnikova OM, McGuffog L, Healey S, Nevanlinna H, Heikkinen T, Simard J, Spurdle AB, Beesley J, Chen X; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Neuhausen SL, Ding YC, Couch FJ, Wang X, Fredericksen Z, Peterlongo P, Peissel B, Bonanni B, Viel A, Bernard L, Radice P, Szabo CI, Foretova L, Zikan M, Claes K, Greene MH, Mai PL, Rennert G, Lejbkowicz F, Andrulis IL, Ozcelik H, Glendon G; OCGN, Gerdes AM, Thomassen M, Sunde L, Caligo MA, Laitman Y, Kontorovich T, Cohen S, Kaufman B, Dagan E, Baruch RG, Friedman E, Harbst K, Barbany-Bustinza G, Rantala J, Ehrencrona H, Karlsson P, Domchek SM, Nathanson KL, Osorio A, Blanco I, Lasa A, Benítez J, Hamann U, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, van der Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, van Roozendaal CE; HEBON, Peock S, Cook M, Frost D, Oliver C, Platte R, Evans DG, Lalloo F, Eeles R, Izatt L, Davidson R, Chu C, Eccles D, Cole T, Hodgson S; EMBRACE, Godwin AK, Stoppa-Lyonnet D, Buecher B, Léoné M, Bressac-de Paillerets B, Remenieras A, Caron O, Lenoir GM, Sevenet N, Longy M, Ferrer SF, Prieur F; GEMO, Goldgar D, Miron A, John EM, Buys SS, Daly MB, Hopper JL, Terry MB, Yassin Y; Breast Cancer Family Registry, Singer C, Gschwantler-Kaulich D, Staudigl C, Hansen TO, Barkardottir RB, Kirchhoff T, Pal P, Kosarin K, Offit K, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Schwartz PE, Blank SV, Toland AE, Montagna M, Casella C, Imyanitov EN, Allavena A, Schmutzler RK, Versmold B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Deissler H, Fiebig B, Suttner C, Schönbuchner I, Gadzicki D, Caldes T, de la Hoya M, Pooley KA, Easton DF, Chenevix-Trench G; CIMBA. Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 18(22): 4442-56

IF 7,249

 

Pfeiler G, Hudelist G, Wülfing P, Mattsson B, Königsberg R, Kubista E, Singer CF. Impact of AdipoR1 expression on breast cancer development (2010) Gynecol Oncol.,Jan 11. [Epub ahead of print]

IF 2,919

 

Neuhausen SL, Brummel S, Ding YC, Singer CF, Pfeiler G, Lynch HT, Nathanson KL, Rebbeck TR, Garber JE, Couch F, Weitzel J, Narod SA, Ganz PA, Daly MB, Godwin AK, Isaacs C, Olopade OI, Tomlinson G, Rubinstein WS, Tung N, Blum JL, Gillen DL (2009) Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. Breast Cancer Res. Oct 20;11(5):R76. [Epub ahead of print]

IF 5,050

 

Osorio A, Milne RL, Pita G, Peterlongo P, Heikkinen T, Simard J, Chenevix-Trench G, Spurdle AB, Beesley J, Chen X, Healey S; KConFab, Neuhausen SL, Ding YC, Couch FJ, Wang X, Lindor N, Manoukian S, Barile M, Viel A, Tizzoni L, Szabo CI, Foretova L, Zikan M, Claes K, Greene MH, Mai P, Rennert G, Lejbkowicz F, Barnett-Griness O, Andrulis IL, Ozcelik H, Weerasooriya N; OCGN, Gerdes AM, Thomassen M, Cruger DG, Caligo MA, Friedman E, Kaufman B, Laitman Y, Cohen S, Kontorovich T, Gershoni-Baruch R, Dagan E, Jernström H, Askmalm MS, Arver B, Malmer B; SWE-BRCA, Domchek SM, Nathanson KL, Brunet J, Ramón Y Cajal T, Yannoukakos D, Hamann U; HEBON, Hogervorst FB, Verhoef S, Gómez García EB, Wijnen JT, van den Ouweland A; EMBRACE, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Luccarini C, Evans DG, Lalloo F, Eeles R, Pichert G, Cook J, Hodgson S, Morrison PJ, Douglas F, Godwin AK; GEMO, Sinilnikova OM, Barjhoux L, Stoppa-Lyonnet D, Moncoutier V, Giraud S, Cassini C, Olivier-Faivre L, Révillion F, Peyrat JP, Muller D, Fricker JP, Lynch HT, John EM, Buys S, Daly M, Hopper JL, Terry MB, Miron A, Yassin Y, Goldgar D; Breast Cancer Family Registry, Singer CF, Gschwantler-Kaulich D, Pfeiler G, Spiess AC, Hansen TV, Johannsson OT, Kirchhoff T, Offit K, Kosarin K, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Schwartz PE, Blank SV, Toland AE, Montagna M, Casella C, Imyanitov EN, Allavena A, Schmutzler RK, Versmold B, Engel C, Meindl A, Ditsch N, Arnold N, Niederacher D, Deissler H, Fiebig B, Varon-Mateeva R, Schaefer D, Froster UG, Caldes T, de la Hoya M, McGuffog L, Antoniou AC, Nevanlinna H, Radice P, Benítez J; CMBA (2009) Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) Br J Cancer 101(12):2048-54

IF 4,846

 

Filipits M, Rudas M, Heinzl H, Jakesz R, Kubista E, Lax S, Schippinger W, Dietze O, Greil R, Stiglbauer W, Kwasny W, Nader A, Stierer M, Gnant MF; Austrian Breast and Colorectal Cancer Study Group (Collaborator Singer C);. Low p27 expression predicts early relapse and death in postmenopausal hormone receptor-positive breast cancer patients receiving adjuvant tamoxifen therapy (2009) Clin Cancer Res. 15(18):5888-94

IF 6,488

 

Fink-Retter A, Czerwenka K, Gschwantler-Kaulich D, Hudelist G, Pischinger K, Manavi M, Kubista E, Singer CF (2009) Proteomics in mammary cancer research. Eur J Gynaecol Oncol. 2009;30(6):635-9.

IF 0,641

 

Rebbeck TR, Mitra N, Domchek S, Wan F, Chuai S, Friebel T, Panossian S, Spurdle A, Chenevix-Trench G, KConFab, Singer CF, Pfeiler G, Neuhausen S, Lynch H, Garber J, Weitzel J, Isaacs C, Couch F, Narod S, Rubinstein W, Tomlinson G, Ganz P, Olopade O, Tung N, Blum J, Greenberg R, Nathanson K, Daly M (2009) Modification of Ovarian Cancer Risk by BRCA1/2 Interacting Genes in a Multicenter Cohort of BRCA1/2 Mutation Carriers. Cancer Research 69(14): 5801-10

IF 7,672

 

Grunt TW, Wagner R, Grusch M, Berger W, Singer CF, Marian B, Zielinski CC, Lupu R (2009) Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells. Biochemical and Biophysical Research Communications 385(3): 454-9.

IF 2,749

 

Hudelist G, Oberwinkler KH, Singer CF, Tuttlies F, Rauter G, Ritter O, Keckstein J (2009) Combination of Transvaginal Sonography (TVS) and Clinical Examination (PV) for Preoperative Diagnosis of Pelvic Endometriosis, Hum Repr 24(5): 1018-24

IF 3,543

 

Johnatty SE, Couch FJ, Fredericksen Z, Tarrell R, Spurdle AB, Beesley J, Chen X; kConFab Investigators; AOCS Group; The Swedish BRCA1 and BRCA2 Study Collaborators, Gschwantler-Kaulich D, Singer CF, Fuerhauser C, Fink-Retter A, Domchek SM, Nathanson KL, Pankratz VS, Lindor NM, Godwin AK, Caligo MA, Hopper J, Southey MC, Giles GG, Justenhoven C, Brauch H, Hamann U, Ko YD, Heikkinen T, Aaltonen K, Aittomäki K, Blomqvist C, Nevanlinna H, Hall P, Czene K, Liu J, Peock S, Cook M, Platte R, Gareth Evans D, Lalloo F, Eeles R, Pichert G, Eccles D, Davidson R, Cole T, Cook J, Douglas F, Chu C, Hodgson S, Paterson J, Hogervorst FB, Rookus MA, Seynaeve C, Wijnen J, Vreeswijk M, Ligtenberg M, van der Luijt RB, van Os TA, Gille HJ, Blok MJ; HEBON, Issacs C, Humphreys MK, McGuffog L, Healey S, Sinilnikova O, Antoniou AC, Easton DF, Chenevix-Trench G; on behalf of the Breast Cancer Association Consortium and the Consortium of Investigators of Modifiers of BRCA1/2. No evidence that GATA3 rs570613 SNP modifies breast cancer risk. Breast Cancer Res Treat. 2008 Dec 11. [Epub ahead of print]

IF: 4,453

 

Singer CF, Hudelist G, Fuchs E, Köstler W, Fink-Retter A, Gschwantler-Kaulich D, Gnant M, Lamm W, Rudas M, Czerwenka K, Kubista E (2009) Incomplete Surgical Resection of DCIS Results in Activation of HER-2 in Residual Breast Cancer Cells, Endocrine-Related Cancer 16(1): 73-83

IF: 5,193

 

Kenemans P, Bundred NJ, Foidart JM, Kubista E, von Schoultz B, Sismondi P, Vassilopoulou-Sellin R, Yip CH, Egberts J, Mol-Arts M, Mulder R, van Os S, Beckmann MW, LIBERATE Study Group (Collaborator Singer CF) (2009) Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial, Lancet Oncol 10(2): 135-46

                                                                                                                                IF 12,247

 

Singer CF, Gschwantler-Kaulich D, Fink-Retter A, Pfeiler G, Walter, I, Hudelist G, Helmy S, Spiess A, Lamm W, and Kubista E (2008) Lamm, and Ernst Kubista (2009) HER2 overexpression and activation, and tamoxifen efficacy in receptor-positive early breast cancer, J Cancer Res Clin Oncol 135(6): 807-13

                                                                                                                     IF: 2,366

 

Hudelist G, Huber A, Auer M, Knöfler M, Saleh L, Hrachowitz C, Huber JC, Kubista E, Manavi M, and Singer CF (2009) Administration of beta-HCG leads to dose-dependent changes of gene expression signature of endometriotic stromal cells. J Cancer Res Clin Oncol, accepted       

IF: 2,366

 

Singer CF (2008) Neoadjuvant endocrine therapy in breast cancer Breast Care 3(5): 303-311     

                                                                                                                     IF: 0,040

 

Hudelist G, Wuelfing P, Czerwenka K, Knöfler M, Haider S, Fink-Retter A, Gschwantler-Kaulich D, Pfeiler G, Kubista E, Singer CF (2009) Beta-hCG/LH receptor (b-HCG/LH-R) expression is increased in invasive versus preinvasive breast cancer: implications for breast carcinogenesis? J Cancer Res Clin Oncol. 135 (2): 191-195                     

                                                                                  IF: 2,366

 

Singer CF (2008) Climacteric complaints after breast cancer - Is HRT an option? Breast Care, 3:204-209

                                                                                                                     IF: 0,040

 

Singer CF, Koestler WJ, and Hudelist G (2008) Predicting the efficacy of trastuzumab-based therapy in breast cancer: current standards and future strategies BBA - Reviews on Cancer, 1786(2):105-13

IF: 7,264

 

Bennink HJTC, Singer C, Simoncini T, Genazzani AR, Holinka CF, Kubista E (2008) Estetrol, a pregnancy-specific human steroid, prevents and suppresses mammary tumor growth in a rat model Climacteric 11(Suppl.1): 29                                                           

IF: 2,275

 

Mlineritsch B, Tausch C, Singer C, Luschin-Ebengreuth G, Jakesz R, Ploner F, Stierer M, Melbinger E, Menzel C, Urbania A, Fridrik M, Steger G, Wohlmuth P, Gnant M, Greil R; on behalf of the Austrian Breast, Colorectal Cancer Study Group (ABCSG). (2008) Exemestane as primary systemic treatment for hormone receptor positive post-menopausal breast cancer patients: a phase II trial of the Austrian Breast and Colorectal Cancer Study Group (ABCSG-17). Breast Cancer Res Treat 14(6):1767-74

                                                                                                                     IF: 4,453

 

Rudas M, Lehnert M, Huynh A, Jakesz R, Singer C, Lax S, Schippinger W, Dietze O, Greil R, Stiglbauer W, Kwasny W, Grill R, Stierer M, Gnant MF, Filipits M; for the Austrian Breast and Colorectal Cancer Study Group (2008) Cyclin D1 Expression in Breast Cancer Patients Receiving Adjuvant Tamoxifen-Based Therapy. Clin Cancer Res 14(6):1767-1774                                     

IF: 6,250

 

Hudelist G, Huber A, Knoefler M, Haider S, Kolbus A, Czerwenka K, Helmy S, Kubista E, and Singer CF (2008) Beta-hCG/LH receptor (b-HCG/LH-R) expression in eutopic endometrium and endometriotic implants: evidence for b-HCG sensitivity of endometriosis, Repr Sciences, 15(6): 543-51   

IF: 2,379

 

Hudelist G, Wülfing P, Kersting C, Burger H, Mattsson B, Czerwenka K, Kubista E, Gschwantler-Kaulich D, Fink-Retter A, Singer CF (2008) Expression of aromatase and estrogen sulfotransferase in preinvasive and invasive breast cancer. J Cancer Res Clin Oncol 134(1):67-73                   

IF: 2,366

 

Hudelist G, Czerwenka K, Keckstein J, Haas C, Fink-Retter A, Gschwantler-Kaulich D, Kubista E, Singer CF (2007) Expression of aromatase and estrogen sulfotransferase (EST) in eutopic and ectopic endometrium - evidence for unbalanced estradiol production in endometriosis Repr Sciences 14(8):798-805                                                                                                            

IF: 2,958

 

Singer CF, Gschwantler-Kaulich D, Fink-Retter A, Haas C, Hudelist G, Czerwenka K, and Kubista E (2008). Differential Gene Expression Profile in Breast Cancer-derived Stromal Fibroblasts, Breast Cancer Res Treat, 110(2):273-81                                                                              

IF: 4,453

 

Hudelist G , Wagner T, Rosner M, Fink-Retter A, Gschwantler-Kaulich D, Czerwenka K, Kroiss R, Tea M, Pischinger K, Köstler WJ, Attems J, Mueller R, Blaukopf C, Kubista E, Hengstschläger M and Singer CF (2007) Intratumoral IGF-1 protein expression is selectively up-regulated in breast cancer patients with BRCA1/2 mutations. Endocrine-Related Cancer 14(4): 1053-1062                             

IF: 4,763

 

Huber A, Hudelist G, Auer M, Knöfler M, Saleh L, Hrachowitz C, Huber JC, Czerwenka K, Kubista E and Singer CF (2007) Effect of highly purified hCG preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of beta-HCG in vivo. Fertil Steril 88: 1232-1239                                                              

IF: 3,168

 

Steger GS, Galid A, Gnant M, Mlineritsch B, Lang A, Tausch C, Rudas M, Greil R, Wenzel C, Singer CF, Haid A, Pöstlberger S, Samonigg H, Luschin-Ebengreuth G, Kwasny W, Klug E, Kubista E, Menzel C, and Jakesz R for the Austrian Breast and Colorectal Cancer Study Group (ABCSG) (2007) Pathologic Complete Response with 6 vs 3 Cycles of Neoadjuvant Epirubicin/Docetaxel plus G-CSF in Operable Breast Cancer: Results of ABCSG –14. J Clin Oncol 25 (15): 2012-2018         

                       IF: 15,484

 

Gschwantler-Kaulich D, Fink-Retter A, Hudelist G, Bachrich T, Ledesma M, Ruecklinger E, Kubista E and Singer CF (2007). Efficacy of primary systemic chemotherapy regimen containing anthracyclines with/without taxanes in comparison to CMF in women with early breast cancer J. Chemother 19(6):731-738

IF: 1,374

 

Kubista E, Planellas-Gomez JVM, Dowsett M, Foidart JM, Pohlodek K, Serreyn R, Nechushkin M, Manikhas AG, Semiglazov VF, Hageluken CCM, and Singer CF (2007). Effect of Tibolone on Breast Cancer Cell Proliferation in postmenopausal ER+ patients: Results from a double-blind, placebo-controlled, randomized Clinical Trial (STEM). Clin Cancer Res 13 (14): 4185-90        

IF: 6,177

 

Hudelist G, Wülfing P, Kersting C, Burger H, Mattsson B, Czerwenka K, Kubista E, Gschwantler-Kaulich D, Fink-Retter A, Singer CF (2007). Expression of aromatase and estrogen sulfotransferase (EST) in preinvasive and invasive breast cancer. J Cancer Res Clin Oncol 134(1):67-73         

IF: 2,366

 

Reich O, Hudelist G and Singer CF (2006) Estrogen Sulphotransferase Expression in Endometrial Stromal Sarcomas: an Immunohistochemical Study, Pathology - Research and Practice, 203 (2): 85-87

                                                                                                                     IF: 0,892

Singer CF, Fink-Retter A, Gschwantler-Kaulich D, Thalhammer T, Hudelist G, Mueller R, Czerwenka K and Kubista E (2006) Selective spatial up-regulation of intratumoral stromal aromatase in breast cancer patients: evidence for imbalance of local estrogen metabolism Endocrine-Related Cancer, 13: 1101-1107

                                                                                                                     IF: 4,905

 

Fink-Retter A, Gschwantler-Kaulich D, Hudelist G, Mueller R, Kubista E, Czerwenka K and Singer CF (2007) Differential spatial expression and activation pattern of EGFR and HER2 in human breast cancer. Oncology Reports, 18 (2): 299-304                                                             

IF: 1,567

 

Singer CF, Hudelist G, Gschwantler-Kaulich D, Fink-Retter A, Mueller R, Walter I, Czerwenka K and Kubista E (2006) Interleukin-1 alpha protein secretion in breast cancer is associated with poor differentiation and estrogen receptor alpha negativity Int J Gynecol Cancer 16, Suppl 2: 556-559

                                                                                                                     IF: 1,147

 

Hudelist G, Singer CF, Pischinger K, Kaserer K, Manavi M, Kubista E, Czerwenka K (2006) Proteomic Analysis in Human Breast Cancer: Identification of a Characteristic Protein Expression Profile of Malignant Breast Epithelium Proteomics, 6: 1989 -2002                                                      

IF: 5,735

 

Singer CF and Hudelist G, Walter I, Rueckliniger E, Czerwenka K, Kubista E and Huber AV (2006) Tissue array-based expression of transglutaminase-2 in human breast and ovarian cancer Clin & Experiment Metastasis, 23(1):33-9                                                                                           

IF: 3,048

 

Gschwantler-Kaulich D, Fink-Retter A, Kubista E and Singer CF (2006) Prädiktive Onkologie. Gyn-Aktiv 1/06: 23-25

 

Langer S, Singer CF, Hudelist G, Dampier B, Kaserer K, Vinatzer U, Pehamberger H, Zielinski CC, Kubista E and Schreiber M Jun and Fos family protein expression in human breast cancer: Correlation of protein expression and clinicopathological parameters (2006) Europ J Gynecol Oncol, 27(4): 345-352

                                                                                                                     IF: 2,887

 

Singer CF, Hudelist G, Lamm W, Mueller R, Handl C, Kubista E and Czerwenka K (2006) Active (p)CrkL is overexpressed in human malignancies: potential role as a surrogate parameter for therapeutic tyrosine kinase inhibition, Oncology Reports 15(2): 353-359                                         

IF: 1,572

 

Gschwantler-Kaulich D, Fink-Retter A, Kubista E and Singer CF (2006) Kosteneffektivität von Herceptin. Gyn-Aktiv 1/06: 20-21

 

Köstler WJ, Hudelist G, Rabitsch W, Czerwenka K, Müller R, Singer CF and Zielinski CC (2006) Insulin-like growth factor-I receptor (IGF-IR) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer, J Canc Res Clin Oncol 132(1): 9-18                                                                                                        

IF: 2,503

 

Hudelist G and Köstler WJ, Czerwenka K, Kubista E,Attems J, Müller R, Gschwantler-Kaulich D, Manavi M, Huber I, Hoschützky H, Zielinski CC and Singer CF (2006) Her-2/neu and EGFR tyrosine kinase activation predict the efficacy of trastuzumab-based therapy in patients with metastatic breast cancer. Int J Cancer, 118(5):1126-34                                                                                                       

IF: 4,700

 

Hudelist G, Köstler WJ, Gschwantler-Kaulich D, Czerwenka K, Kubista E, Müller R, Helmy S, Manavi M, Zielinski CC and Singer CF (2006) Serum EGFR levels and efficacy of trastuzumab-based therapy in patients with metastatic breast cancer. Europ J Cancer, 42(2):186-92                  

IF: 3,706

 

Hudelist G, Keckstein J, Czerwenka K, Lass H, Walter I, Auer M, Wieser F, Wenzl R, Kubista E and Singer CF (2005) Estrogen receptor beta and matrix metalloproteinase-1 are co-expressed in uterine endometrium and endometriotic lesions of patients with endometriosis. Fertil Steril, 84 Suppl 2:1249-56

                                                                                                                     IF: 3,114

 

Hudelist G, Singer CF and Keckstein J (2005) Matrix-Metalloproteinasen (MMPs) und deren Bedeutung für die Menstruation und Endometriose. Zentralbl Gynakol 127: 318-322

 

Singer CF (2005) Herceptin – adjuvante Therapie des Mammakarzinoms. Ein neuer Standard. Gyn-Aktiv 5: 14-16

 

Hudelist G, Keckstein J, Czerwenka K, Lass H, Walter I, Auer M, Wieser F, Wenzl R, Kubista E, and Singer CF (2005) Estrogen receptor alpha and matrix metalloproteinase 1 are co-expressed in uterine endoemtrium and endometriotic lesions of patients with endometriosis. Fertil Steril, 84 Suppl 2:1249-56

                                                                                                                     IF: 3,114

 

Gschwantler-Kaulich D, Fink A, Kubista E and Singer CF (2005) Predictive Oncology. Senologie, 4/2005: 8-9                                                                                                

 

Hudelist G, Singer CF, Kubista E, and Czerwenka K (2005) Use of high-throughput arrays for profiling differentially expressed proteins in normal and malignant tissues. Anticancer Drugs 16(7): 683-689

                                                          IF: 1,907

 

Gschwantler-Kaulich D, Hudelist G, Koestler WJ, Czerwenka K, Mueller R, Ruecklinger E, Kubista E and Singer CF (2005) EGFR activity in HER-2 over-expressing metastatic breast cancer: evidence for simultaneous phosphorylation of Her-2/neu and EGFR. Oncology Reports 14(2): 305-11

                                                                                                                     IF: 1,572

 

Hudelist G, Lass H, Keckstein J, Walter I, Wieser F, Wenzl F, Mueller R, Czerwenka K, Kubista E, and Singer CF (2005) Interleukin 1 alpha (IL1a) and tissue-lytic matrix metalloproteinase-1 (MMP-1) are elevated in ectopic endometrium of patients with endometriosis.  Human Reproduction 20(6): 1695-701

                                                                                                                     IF: 3,669

 

Singer CF and Kubista E (2005) Prädiktive Onkologie. Speculum – Zeitschrift für Gynäkologie und Frauenheilkunde 23 (1): 9-11

 

Koestler WJ, Brodowicz T, Hudelist G, Rudas M, Horvat R, Steger GG, Singer CF, Attems J, Rabitsch W, Fakhrai N, Elandt K, Wiltschke C, Hejna M, and Zielinski CC (2005) The Efficacy of Trastuzumab in Her-2/neu Overexpressing Metastatic Breast Cancer is Independent from p53 Status. J Cancer Research and Clinical Oncology 131(7): 420-428                                                                  

IF: 2,366

 

Singer CF (2005) Herzeptintherapie – Neue Indikationen? GYN-AKTIV, 1:15-18

 

Koestler W, Steger GG, Krainer M, Kornek G, Locker G, Brodowicz T, Marosi C, Singer CF, Hudelist G, Rabitsch W, Wiltschke C, and Zielinski CC (2005) Single Agent Trastuzumab versus Trastuzumab plus Cytotoxic Chemotherapy in Metastatic Breast Cancer: A single Institution Experience. Anticancer Drugs 16(2):185-90                                                                                                    

IF: 1,907

 

Hudelist G, Gellen J, Singer CF, Ruecklinger E, Czerwenka K, Kandolf O, and Keckstein J (2005) Occurrence and risk factors predicting severe perineal trauma during childbirth in a referral hospital: role of assisted vaginal delivery. American Journal of Obstetrics and Gynecology 193:875-881              

                                                                                                                     IF : 3,083

 

Huber A, Hudelist G, Czerwenka K, Husslein P, Kubista E, and Singer CF (2005) Cervical effacement is associated with a characteristic gene expression profile in the cDNA Array analysis of cervical biopsies American Journal of Obstetrics and Gynecology, 105(1): 91-98                          

IF: 3,083

 

Hudelist G, Czerwenka K, Singer CF, Pischinger K, Kubista E, and Manavi M (2005) Cytobrush-collected malignant cervical epithelial cells display a cancer-specific gene expression pattern in cDNA Array analysis. Cancer Genetics and Cytogenetics 158,1:35-42                                              

IF: 1,640

 

Huber AV, Huber CJ, Kolbus A, Martin Imhof M, Nagele F, Loizou D, Kaufmann U, and Singer CF (2004) Effects of Systemic HCG Treatment on Patients with Endometriosis: a New Perspective for a Painful Disease. Wien Klin Wochenschr 116 (24): 839-843                                             

IF: 0,774

 

Singer CF, Hudelist G, Lamm W, Mueller  R, Czerwenka K, and Kubista E (2004) Expression of membrane-associated tyrosin kinases in human malignancies as potential targets for kinase-specific inhibitors. Endocrine Related Cancer 11(4): 861-869                                     

IF: 8,894

 

Hudelist G, Singer CF, Kubista E, Mueller R, and Czerwenka K (2004) Nanobacteria - a possible cause for the development of psammoma bodies in ovarian cancer. Histopathology 45: 633-637

                                                                                                                     IF: 2,952

 

Hudelist G, Pacher M, Singer CF, Holper T, Kubista E, Schreiber M, Manavi M, Bilban M, and Czerwenka K (2004) Use of high-throughput protein arrays for profiling of differentially expressed proteins in normal and malignant breast tissue. Breast Cancer Research and Treatment, 86(3): 283-293

                                                                                                                     IF: 2,964

 

Grunt TW, Singer CF, and Solca F (2004) Disease Models of Cancer: HER2 And Breast Cancer, Drug Discovery Today: Disease Models 1 (1): 17-23                                                 

IF: 4,934

 

Hudelist G, Koestler W, Czerwenka K, Kubista E, and Singer CF (2004) Predicting the clinical course of breast cancer patients undergoing trastuzumab-based therapy: an outlook, Methods Find Exp Clin Pharmacol. 26 (3): 201-210                                                                           

IF: 0,613

 

Koestler WJ, Steger GG, Soleiman A, Schwab B, Singer CF, Tomek S, Brodowicz T, Krainer M, Wiltschke C, Horvat R, Jakesz R, and Zielinski CC (2004) Monitoring of Serum Her-2/neu Predicts Histopathologic Response to Neoadjuvant Trastuzumab-based Therapy for Breast Cancer, Anticancer Research, 24: 1127-1130                                                                           

IF: 1,347

 

Singer CF, Mogg M, Koestler W, Marton E, Pacher M, Kubista E, and Schreiber M (2004) IGF-1 and IGF-2 Serum Concentrations in Patients with Benign and Malignant Breast Lesions: Free IGF-2 is Correlated with Breast Cancer Size. Clinical Cancer Res 10: 4003-4009                       

IF: 6,511

 

Hudelist G, Manavi M, Pischinger KI, Watkins-Riedel T, Singer CF, Kubista E, and Czerwenka KF (2004) Physical state and expression of HPV DNA in benign and dysplastic cervical tissue: different levels of viral integration are correlated with lesion grade. Gynecol Oncol 92(3): 873-880         

IF: 2,341

 

Koestler WB, Schwab B, Singer CF, Neumann R, Rücklinger E, Marton E, Brodowicz T, Tomek S, Hejna M, Steger G, Krainer M, Wiltschke C, and Zielinski CC (2004) Monitoring of Serum Her-2/neu predicts Response and Progression-free Survival to Trastuzumab in Patients with Metastatic Breast Cancer, Clinical Cancer Res 10: 1618-1624                                                              

IF: 6,511

 

Asseryanis, E, Ruecklinger, E, Hellan, M, Kubista, E and Singer CF (2004) Breast Cancer Size is correlated with body mass index and androgen serum levels. Gynecological Endocrinology 18 (1): 29-36

                                                                                                                     IF: 0,870

 

Singer CF, Kronsteiner N, Hudelist G., Marton E, Walter I,  Kubista M, Czerwenka, K, Schreiber M, Seifert M, and Kubista E (2003) IL-1 system and sex steroid receptor expression in human breast cancer: IL-1alpha protein secretion is correlated with malignant phenotype, Clinical Cancer Res 9: 4877-4883

                                                                                                                     IF: 5,623

 

Hudelist G, Kostler WJ, Attems J, Czerwenka K, Muller R, Manavi M, Steger GG, Kubista E, Zielinski CC, and Singer CF (2003) Her-2/neu-triggered intracellular tyrosine kinase activation: in vivo relevance of ligand-independent activation mechanisms and impact upon the efficacy of trastuzumab-based treatment. Br J Cancer  89: 983-991                                                                        

IF: 3,639

 

Hudelist G, Singer CF, Manavi M, Pischinger K, Kubista E, Czerwenka K (2003) Co-expression of ErbB-family members in human breast cancer: Her-2/neu is the preferred dimerization candidate in nodal-positive tumors. Breast Cancer Res Treat  80: 353-361                                        

IF: 3,132

 

Koestler WJ, Amann G, Grunt TW, Singer CF, Schneider SM, Brodowicz T, Tomek S and Zielinski CC. (2003) Recurrent Malignant Triton Tumour - First report on a long time survivor, Oncology Reports 10(3): 533-535                                                                                                

IF: 1,171

 

Hudelist G, Czerwenka K, Kubista E, Marton E, Pischinger K, and Singer CF (2003) Expression of Sex Steroid Receptors and their Co-factors in Normal and Malignant Breast Tissue: AIB1 Is a Carcinoma-Specific Co-Activator, Breast Cancer Research and Treatment 78 (2): 193-204   

IF: 3,132

 

Singer CF, Hudelist G, Schreiber M, and Kubista E (2003) Pharmacological modulation of IGF concentrations as a therapeutical approach in controlling the size of malignant breast tumors, Drugs Today 39 (2): 115-125                                                                                          

IF: 0,258

 

Jelincic D, Hudelist G, Singer CF, Bauer M, Horn LC, Bilek K, and Czerwenka K (2003) Klinisches und pathologisches Profil gestationsbedingter Trophoblast-tumoren. Wiener Klinische Wochenzeitschrift 115 (1-2): 29-35                                                                                                     

IF: 0,591

 

Wieser F, Schneeberger C, Hudelist G, Singer C, Kurz C, Nagele F, Gruber C, Huber JC and Tschugguel W. (2002) Endometrial nuclear receptor co-factors SRC-1 and N-CoR are increased in Human Endometrium during menstruation, Molecular Human Reproduction, 8 (7): 644-650

                                                                                                                     IF: 2,751

 

Singer CF, Kronsteiner N, Marton E, Walter I, Kubista M, Czerwenka K, Schreiber M, Tschugguel W, Wieser F, Kubista E (2002) IL-1alpha gene expression in human endometrial cancer is independent of ovarian steroid receptor expression. Eur J Cancer 38(Suppl 6): 76-77                  

IF : 3,562

 

Hirtenlehner K, Pec M, Kubista E, and Singer CF (2002) Extracellular Matrix Proteins influence phenotype and cytokine expression of human breast cancer cell lines, Eur Cytokine Netw 13: 234-240

                                                                                                                     IF: 1,677

 

Hirtenlehner K, Pec M, Kubista E, and Singer CF (2002) Influence of stroma-derived growth factors on the cytokine expression pattern of human breast cancer cell lines Archives of Gynecology and Obstetrics 266 (2): 108-13                                                                                                

IF: 0,666

 

Singer CF, Kronsteiner N, Marton E, Walter I, Kubista M, Czerwenka K, Schreiber M, Tschugguel W, Wieser F, and Kubista E (2002) IL-1 system and sex steroid receptor gene expression in human endometrial cancer, Gynecol Oncol  85 (3): 423-430                                   

IF: 2,200

 

Singer CF, Kronsteiner N, Marton E, Kubista M, Cullen, KJ, Hirtenlehner K, Seifert M, and Kubista E (2002) MMP-2 and MMP-9 expression in breast cancer-derived human fibroblasts is differentially regulated by stromal-epithelial interactions, Breast Cancer Res. and Treat. 72 (1): 69-77

                                                                                                                     IF: 2,866

 

Henriet P, Cornet P, Lemoine P, Singer CF, Courtoy PJ, Eeckhout Y, and Marbaix E (2002) Circulating sex hormones and endometrial matrix metalloproteinases (MMPs), Annals N.Y. Acad. Sci. 955: 119-139

                                                                                                                     IF: 1,593

 

Singer CF, Kubista E, Garmroudi F, and Cullen KJ (2000) Local feedback mechanisms in human breast cancer. Breast Cancer Res. and Treat. 63: 95-104                                      

IF: 2,889

 

Singer CF, Marbaix E, Kokorine I, Lemoine P, Donnez J, Eeckhout Y, and Courtoy PJ (2000) The Matrix metalloproteinase-1 (MMP-1) expression in the human endometrium is inversely regulated by interleukin-1alpha and sex steroids. Cescá Gynecologie 65: 211-215

 

Obwegeser R, Berghammer P, Rodrigues M, Granegger S, Hohlagschwandtner M, Kucera H, Singer C, Berger A, Kubista E, and Sinzinger H (1999) A head-to-head comparison between 99M-Tc-Tetrofosmin and 99M-Tc-MIBI scintigraphy to evaluate suspicious breast lesions. Eur. J. Nucl. Med., 26, 1553-1559

                                                                                                                     IF: 3,239

 

Singer CF, Marbaix E, Lemoine P, Eeckhout Y, and Courtoy PJ (1999) Interleukin-1 receptor-ligand interactions modulate interstitial collagenase-1 production by human endometrial fibroblasts. Mol. Hum. Reprod., 5, 240-245        [nbsp

Lehr- und wissenschaftliche Tätigkeiten

Professor an der Medizinischen Universität Wien, Foschrungsschwerpunkt Brustkrebs und Wechselbeschwerden.